A Guide to First Dose and Last Dose Missions in GTA Online

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Grand Theft Auto Online offers a thrilling mix of missions, heists, and activities to keep players hooked. With the introduction of the Los Santos Drug Wars update, Rockstar Games spiced things up with a fresh narrative revolving around the psychedelic business. This update brought two distinct mission series: First Dose and Last Dose.

If you’re venturing into the world of Los Santos’ latest drug craze, you might be wondering – how many missions are there in each series, and how do I unlock them? This comprehensive guide will break down everything you need to know about these missions, including their objectives, rewards, and how to trigger them.

Grand Theft Auto

Unveiling the First Dose: A Stepping Stone to Acid Profits

The First Dose missions serve as an introductory chapter to the Los Santos Drug Wars storyline. Here, you’ll team up with a familiar face – Trevor’s associate, Ron – to tackle various tasks involving the burgeoning psychedelic operation.

There are a total of six First Dose missions you can play through. Let’s delve into what each mission entails:

Fire It Up: This introductory mission kicks things off with Ron calling you for backup at the Ace Liquor store. You’ll encounter the Fooliganz gang causing trouble and need to eliminate them to restore order.

Buzzkill: In this mission, Ron seeks your help in retrieving a stolen chemical shipment from the Vagos gang. Prepare for a shootout to reclaim the essential ingredients for his psychedelic concoction.

Landing Gear:  Here, you’ll be tasked with stealing a specialized aircraft from the Los Santos International Airport. This aircraft plays a crucial role in smuggling supplies for Ron’s operation.

Freeway Freakout:  This mission involves retrieving a chemist named Lachlan from the clutches of the police. Expect a high-speed chase and a potential shootout to secure Lachlan’s freedom.

Tangled Up in Blue:  In this mission, you’ll be working undercover with the LSPD (Los Santos Police Department) to infiltrate a sting operation targeting the Fooliganz. Be prepared to take down gang members and escape with incriminating evidence.

Acid Lab Setup:  The final First Dose mission culminates in setting up Ron’s Acid Lab, the heart of his psychedelic operation. This mission involves stealing a tanker truck filled with essential chemicals and delivering it safely to the lab.

Triggering the First Dose Missions: A Helping Hand from Ron

Unlike some missions in GTA Online, the First Dose series doesn’t have a specific character you need to contact to initiate them.  Here’s the key:

You’ll need to be at least level 100 in GTA Online to unlock the First Dose missions.

Once you meet the level requirement, you just need to be in a public lobby and remain idle for a while. This will trigger a call from Ron, who’ll request your assistance at the Ace Liquor store.

Pro Tip: If you don’t receive the call after waiting a while, try switching lobbies or restarting your game.

The Last Dose: Culminating the Acid Lab Business

The Last Dose missions build upon the foundation laid in the First Dose series. Here, you’ll help Ron navigate various challenges threatening the success of his Acid Lab business.

There are a total of five Last Dose missions available:

This Isn’t Intervention:  This mission involves dealing with a group of protestors who have gathered outside the Acid Lab, causing a nuisance. You’ll need to disperse them using non-lethal means.

Unusual Suspects:  In this mission, strange occurrences plague the Acid Lab, leading Ron to suspect Lachlan is tampering with the product. You’ll need to confront Lachlan and get to the bottom of the situation.

Fried Mind:  Here, things take a psychedelic turn as you experience a trippy vision through Lachlan’s perspective. This mission is more objective-based and involves navigating a distorted environment.

Checking In:  This mission brings a potential buyer, the Fooliganz leader Grim Pinchers, to the Acid Lab. However, things go south, and you’ll need to eliminate Grim Pinchers and his crew to protect the business.

BDKD (Big Dose Kill Disruption):  The final Last Dose mission is an all-out brawl as the IAA (International Affairs Agency) raids the Acid Lab. You’ll need to defend the lab from a relentless assault and secure Ron’s psychedelic empire.

FAQ’S

How Many Dose Missions Are There?

There are actually two sets of Dose Missions in GTA Online, each with its own storyline:

First Dose Missions: There are a total of six First Dose missions in GTA Online. These missions introduce you to the psychedelic business and the struggle between the Fooliganz and The Lost MC.

Last Dose Missions:  Once you complete the First Dose missions, you’ll unlock the five Last Dose missions. This series focuses on wrapping up the psychedelic business plot and taking down the rival gang.

How Do I Unlock the Dose Missions?

To unlock the Dose Missions, you’ll need to be at least level 50 in GTA Online. Once you meet this level requirement, you just need to wait for a call! Here’s how it works:

First Dose Missions: While idling in a public lobby, you’ll receive a call from Ron, Trevor’s associate from the main story mode. He’ll request your help at the Ace Liquor store, hinting at trouble with a new crew. Answering this call will trigger the first mission in the series.

Last Dose Missions: After completing all six First Dose missions, you’ll automatically unlock the Last Dose mission sequence. You won’t need another call; you can simply access them through your in-game phone.

What Are the Rewards for Completing Dose Missions?

The Dose Missions offer more than just an exciting storyline. Here’s what you can expect to earn:

Cash: Each mission, both First Dose and Last Dose, pays out a decent sum upon first completion. You can expect around $100,000 per mission. Completing the entire series of each set can net you a cool $500,000 (First Dose) and $500,000 (Last Dose).

Unlockables: Completing the Last Dose missions unlocks the Acid Lab business, allowing you to cook and sell your own psychedelic product. This opens up a whole new income stream and lets you become a major player in the Los Santos drug scene.

Trade Price Discounts:  As you progress through the Dose Missions, you’ll unlock trade price discounts on certain vehicles used throughout the missions. This allows you to purchase them at a significantly reduced cost.

Are There Any Tips for Playing the Dose Missions?

Here are a few pointers to ensure a smooth ride through the Dose Missions:

Come Prepared:  These missions can involve intense shootouts and driving chases.  Make sure you’re well-stocked on ammo, armor, and have a good selection of weapons at your disposal.  Having a fast and reliable vehicle is also a plus.

Team Up: While you can tackle the Dose Missions solo, playing with friends can make things significantly easier.  Having backup can give you a strategic advantage in firefights and help with reviving teammates if things go south.

Explore and Collect: Keep an eye out for hidden stashes and pickups throughout the missions. These can provide you with extra cash, health, and armor, giving you an edge.

Can I Replay the Dose Missions?

Absolutely! Once you’ve unlocked a Dose Mission, you can replay it as many times as you want. This can be a great way to grind for extra cash or simply relive the action-packed story.

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